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This symposium focuses on the role of the major actors of adaptive and innate immunity in the response to HIV: IFN type I response, NK cells, B cells and polyfunctional antibodies, and CD4+ and CD8+ T cells. An overview of each immune actor provides a historical context, following which participants can learn about the latest discoveries in the field before learning how these discoveries can drive the development of successful HIV vaccines, through the induction of effective immune responses in humans. This session is addressed to scientists and clinicians looking for a deep understanding of HIV pathogenesis and the mounting of effective anti-viral immunity, towards the design of efficacious vaccines.

14:30
WESY0501
Introduction
14:35
WESY0502
Polyfunctional antibodies in HIV infection and vaccination
Galit Alter, United States
14:49
WESY0503
CD8+ T cells reborn
Sarah Rowland-Jones, United Kingdom
Slides
15:03
WESY0504
Investigating HIV-specific CD4+ T cell responses through TCR clonotypic analysis: implications for vaccine design
Lisa Chakrabarti, France
Slides
15:17
WESY0505
Mechanisms of HIV-1 resistance to ADCC
David Evans, United States
Slides
15:31
WESY0506
HIV innate sensors and IFN type I response
Nicolas Manel, France
15:45
WESY0507
Moderated discussion
15:55
WESY0508
Closing remarks