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Despite significant strides in HIV management, coinfections are often the direct cause of mortality in severely immunocompromised HIV-positive individuals in sub-Saharan Africa. Due partly to these patients’ immune status, such coinfections can result in unique public health challenges in diagnosis and treatment, especially in resource-limited settings with high multiple disease burden. Major obstacles to effective coinfection management include overlapping toxicities, altered treatment efficacy due to drug-drug interactions, difficulties in medication adherence, and difficulties/delays in diagnosis; for some diseases, there is also a paucity of diagnostic and treatment tools. The symposium will highlight recent advances in HIV/tuberculosis and HIV/cryptococcal coinfections, showcase EDCTP/ANRS-funded projects and present the funding strategy in this area. The following themes will be covered: (1) quantitative diagnostics, (2) advances in efficacious, low toxicity treatments and (3) implementation of treatment algorithms to reduce mortality.

07:00
WESA0401
Brief introduction to EDCTP and ANRS: Description of ongoing projects and funding opportunities
Christy Comeaux, Netherlands
Fran├žois Dabis, France
07:10
WESA0402
Driving REduced AIDS-associated Meningo-encephalitis Mortality in routine care settings in Africa: Update on the DREAMM project
Angela Loyse, United Kingdom
Slides
07:22
WESA0403
High Dose AMBISOME on a Fluconazole Backbone for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: A Randomised Controlled Non-inferiority Trial
Joseph Jarvis, Botswana
Slides
07:34
WESA0404
Decreasing mortality in HIV-infected adults with severe immune suppression: The STATIS (ANRS 12290) randomized trial
Francois-Xavier Blanc, France
Slides
07:46
WESA0405
Reducing mortality among advanced stage HIV-infected persons and the translation of a life saving package of care to inform scale-up in real-life settings in sub-Saharan Africa
Sayoki Mfinanga, United Republic of Tanzania
Slides
07:58
WESA0406
Discussion, led by Andrew Kambugu, with an introductory talk from Nathan Ford, WHO, on the new Advanced Disease Guidelines
Nathan Ford, Switzerland
Slides