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This workshop focuses on the role of persistent immune activation and inflammation in the residual disease of HIV-positive patients receiving ART, from the role of the microbiome to interventions to reduce systemic immune activation, immune ageing and co-morbidities in HIV-positive individuals. Participants at this workshop can learn about issues in confounders and the choice of appropriate controls that are critical to trace the true effect of HIV infection on immune activation and inflammation. This workshop is aimed at scientists and clinicians concerned with a deep understanding of HIV pathogenesis and long term care of treated patients. It provides an historical overview of where we started, through to the latest discoveries that define where we are today, and how these discoveries enable improvements of clinical follow-up and survival for patients.

14:30
MOWS0301
Introduction
Sara Gianella, University of California San Diego (UCSD), United States
Slides
14:39
MOWS0302
Confounding factors and choice of controls in studies of immune activation and inflammation
Caroline Sabin, University College London (UCL), United Kingdom
Slides
14:56
MOWS0303
Role of microbiome and virome and change in mucosal immunity
Douglas Kwon, Ragon Institute of MGH, MIT and Harvard, United States
15:13
MOWS0304
Immune ageing and viral co-factors
Peter Hunt, University of California, San Francisco (UCSF), United States
Slides
15:30
MOWS0305
Inflammatory markers and disease progression in non-human primates
Roger Le Grand, Service Immunologie des Infections Virales et des Maladies Auto-immunes (IMVA), France
Slides
15:47
MOWS0306
Inflammation markers and the risk of non-AIDS events
Linda Wittkop, Bordeaux Population Health, France
Slides
16:04
MOWS0307
Interventions to reduce immune activation
Olivier Lambotte, Paris-Sud University Hospital, France
Slides
16:21
MOWS0308
Round table on markers and interventions
16:51
MOWS0309
Closing remarks